Fetal Programming of Hypertension Induced by Moderate Zinc Restriction during Prenatal Life and Lactation: Early Morphological and Functional Alterations in Cardiovascular System in Both Sexes

Chair of Physiology, School of Pharmacy and Biochemistry, University of Buenos Aires (UBA), Argentina. IQUIMEFA-CONICET Scholar at the University of Buenos Aires. Undergraduate Teaching Assistant, Chair of Physiology, School of Pharmacy and Biochemistry, UBA Undergraduate Teaching Assistant, Chair of Physiology, School of Pharmacy and Biochemistry, UBA Undergraduate Teaching Assistant, Chair of Physiology, School of Pharmacy and Biochemistry, UBA Undergraduate Teaching Assistant, Chair of Physiology, School of Pharmacy and Biochemistry, UBA 5 Ph.D, University of Buenos Aires. Assistant Professional of the CONICET. Head of Practical Assignments, Chair of Physiology, School of Pharmacy and Biochemistry, UBA 6 Ph.D, University of Buenos Aires, Physiology Area. Adjunct Professor, Chair of Physiology, School of Pharmacy and Biochemistry, UBA 7 Independent Researcher of the CONICET. Full Professor, Chair of Physiology, School of Pharmacy and Biochemistry, UBA Ph.D, University of Buenos Aires, Physiology Area. Head of Practical Assignments, Chair of Physiology, School of Pharmacy and Biochemistry, UBA SOURCES OF FUNDING: This study was supported by grants from the University of Buenos Aires (UBACYT: B0008), CONICET (PIP 112200801-01121), IQUIMEFA, CONICET, Argentina. Objective Several studies suggest that metabolic disorders and nutrition imbalance during prenatal life may induce adaptations that program cardiovascular diseases and hypertension. We have previously shown that moderate zinc restriction during prenatal life, lactation and/or growth leads to the development of hypertension and renal dysfunction in adulthood.